iScience
(Feb 2024)
Cooperation between PRMT1 and PRMT6 drives lung cancer health disparities among Black/African American men
Pei-Ying Wu,
Michelle Van Scoyk,
Stephanie S. McHale,
Chu-Fang Chou,
Gregory Riddick,
Kamran Farouq,
Bin Hu,
Vita Kraskauskiene,
Jennifer Koblinski,
Charles Lyons,
Arjun Rijal,
Vignesh Vudatha,
Dongyu Zhang,
Jose G. Trevino,
Rachit D. Shah,
Patrick Nana-Sinkam,
Yong Huang,
Shwu-Fan Ma,
Imre Noth,
Chanita Hughes-Halbert,
Victoria L. Seewaldt,
Ching-Yi Chen,
Robert A. Winn
Affiliations
Pei-Ying Wu
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Michelle Van Scoyk
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Stephanie S. McHale
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Chu-Fang Chou
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Gregory Riddick
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Kamran Farouq
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Bin Hu
Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Vita Kraskauskiene
Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Jennifer Koblinski
Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Charles Lyons
Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Arjun Rijal
Department of Pathology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Vignesh Vudatha
Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Dongyu Zhang
Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Jose G. Trevino
Division of Surgical Oncology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Rachit D. Shah
Division of Cardiothoracic Surgery, Virginia Commonwealth University, Richmond, VA, USA
Patrick Nana-Sinkam
Division of Pulmonary Disease and Critical Care Medicine, Virginia Commonwealth University, Richmond, VA, USA
Yong Huang
Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA
Shwu-Fan Ma
Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA
Imre Noth
Division of Pulmonary and Critical Care, University of Virginia, Charlottesville, VA, USA
Chanita Hughes-Halbert
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA
Victoria L. Seewaldt
City of Hope Comprehensive Cancer Center, Duarte, CA, USA
Ching-Yi Chen
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA
Robert A. Winn
Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, USA; Corresponding author
Journal volume & issue
Vol. 27,
no. 2
Abstract
Read online
Summary: Lung cancer is the third most common cancer with Black/AA men showing higher risk and poorer outcomes than NHW men. Lung cancer disparities are multifactorial, driven by tobacco exposure, inequities in care access, upstream health determinants, and molecular determinants including biological and genetic factors. Elevated expressions of protein arginine methyltransferases (PRMTs) correlating with poorer prognosis have been observed in many cancers. Most importantly, our study shows that PRMT6 displays higher expression in lung cancer tissues of Black/AA men compared to NHW men. In this study, we investigated the underlying mechanism of PRMT6 and its cooperation with PRMT1 to form a heteromer as a driver of lung cancer. Disrupting PRMT1/PRMT6 heteromer by a competitive peptide reduced proliferation in non-small cell lung cancer cell lines and patient-derived organoids, therefore, giving rise to a more strategic approach in the treatment of Black/AA men with lung cancer and to eliminate cancer health disparities.
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