Longitudinal association of epicardial and thoracic adipose tissues with coronary and cardiac characteristics in psoriasis

Ross O'Hagan; Li-Yueh Hsu; Haiou Li; Christin G. Hong; Philip M. Parel; Alexander R. Berg; Grigory A. Manyak; Vy Bui; Nidhi H. Patel; Elizabeth M. Florida; Heather L. Teague; Martin P. Playford; Wunan Zhou; Damini Dey; Marcus Y. Chen; Nehal N. Mehta; Alexander V. Sorokin

Heliyon (Oct 2023)

Longitudinal association of epicardial and thoracic adipose tissues with coronary and cardiac characteristics in psoriasis

Ross O'Hagan,
Li-Yueh Hsu,
Haiou Li,
Christin G. Hong,
Philip M. Parel,
Alexander R. Berg,
Grigory A. Manyak,
Vy Bui,
Nidhi H. Patel,
Elizabeth M. Florida,
Heather L. Teague,
Martin P. Playford,
Wunan Zhou,
Damini Dey,
Marcus Y. Chen,
Nehal N. Mehta,
Alexander V. Sorokin

Affiliations

Ross O'Hagan: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Li-Yueh Hsu: Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA
Haiou Li: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Christin G. Hong: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Philip M. Parel: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Alexander R. Berg: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Grigory A. Manyak: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Vy Bui: Radiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD, USA
Nidhi H. Patel: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Elizabeth M. Florida: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Heather L. Teague: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Martin P. Playford: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Wunan Zhou: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Damini Dey: Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA
Marcus Y. Chen: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Nehal N. Mehta: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA
Alexander V. Sorokin: Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA; Corresponding author. Section of Inflammation and Cardiometabolic Diseases, National Heart, Lung and Blood Institute, Clinical Research Center, 9000 Rockville Pike, Bldg 10, Room 5-5150, Bethesda, MD, 20892, USA.

Journal volume & issue: Vol. 9, no. 10
p. e20732

Abstract

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Background: s: Psoriasis is a disease of systemic inflammation associated with increased cardiometabolic risk. Epicardial adipose tissue (EAT) and thoracic adipose tissue (TAT) are contributing factors for atherosclerosis and cardiac dysfunction. We strove to assess the longitudinal impact of the EAT and TAT on coronary and cardiac characteristics in psoriasis. Methods: The study consisted of 301 patients with baseline coronary computed tomography angiography (CTA), of which 139 had four-year follow up scans. EAT and TAT volumes from non-contrast computed tomography scans were quantified by an automated segmentation framework. Coronary plaque characteristics and left ventricular (LV) mass were quantified by CTA. Results: When stratified by baseline EAT and TAT volume quartiles, a stepwise significant increase in cardiometabolic parameters was observed. EAT and TAT volumes associated with fibro-fatty burden (FFB) (TAT: ρ = 0.394, P < 0.001; EAT: ρ = 0.459, P < 0.001) in adjusted models. Only EAT had a significant four-year time-dependent association with FFB in fully adjusted models (β = 0.307 P = 0.003), whereas only TAT volume associated with myocardial injury in fully adjusted models (TAT: OR = 1.57 95 % CI = (1.00–2.60); EAT: OR = 1.46 95 % CI = (0.91–2.45). Higher quartiles of EAT and TAT had increased LV mass and developed strong correlation (TAT: ρ = 0.370, P < 0.001; EAT: ρ = 0.512, P < 0.001). Conclusions: Our study is the first to explore how both EAT and TAT volumes associate with increased cardiometabolic risk profile in an inflamed psoriasis cohorts and highlight the need for further studies on its use as a potential prognostic tool for high-risk coronary plaques and cardiac dysfunction.

Published in Heliyon

ISSN: 2405-8440 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Science: Science (General); Social Sciences: Social sciences (General)
Website: https://www.cell.com/heliyon/home

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