Emerging Infectious Diseases (Apr 2019)

Enterovirus A71 Phenotypes Causing Hand, Foot and Mouth Disease, Vietnam

  • Hoang Minh Tu Van,
  • Nguyen To Anh,
  • Nguyen Thi Thu Hong,
  • Le Nguyen Truc Nhu,
  • Lam Anh Nguyet,
  • Tran Tan Thanh,
  • Nguyen Thi Han Ny,
  • Vu Thi Ty Hang,
  • Truong Huu Khanh,
  • Ho Lu Viet,
  • Do Chau Viet,
  • Ha Manh Tuan,
  • Nguyen Thanh Hung,
  • Du Tuan Quy,
  • Do Quang Ha,
  • Phan Tu Qui,
  • Le Nguyen Thanh Nhan,
  • Guy Thwaites,
  • Nguyen Van Vinh Chau,
  • Louise Thwaites,
  • H. Rogier van Doorn,
  • Le Van Tan

DOI
https://doi.org/10.3201/eid2504.181367
Journal volume & issue
Vol. 25, no. 4
pp. 788 – 791

Abstract

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We investigated enterovirus A71–associated hand, foot and mouth disease in Vietnam and found that, after replacing subgenogroup C4 in 2013, B5 remained the leading cause of this disease. In contrast with previous observations, this switch did not result in an explosive outbreak, and B5 evolution was driven by negative selection.

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