A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm

Luca Mariani; Xiaogang Guo; Niels Alvaro Menezes; Anna Maria Drozd; Selgin Deniz Çakal; Qinhu Wang; Elisabetta Ferretti

doi:10.1038/s41467-021-25370-4

Nature Communications (Aug 2021)

A TALE/HOX code unlocks WNT signalling response towards paraxial mesoderm

Luca Mariani,
Xiaogang Guo,
Niels Alvaro Menezes,
Anna Maria Drozd,
Selgin Deniz Çakal,
Qinhu Wang,
Elisabetta Ferretti

Affiliations

Luca Mariani: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Xiaogang Guo: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Niels Alvaro Menezes: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Anna Maria Drozd: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Selgin Deniz Çakal: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen
Qinhu Wang: State Key Laboratory of Crop Stress Biology for Arid Areas and College of Plant Protection, Northwest A&F University
Elisabetta Ferretti: Novo Nordisk Foundation Center for Stem Cell Biology (DanStem), University of Copenhagen

DOI: https://doi.org/10.1038/s41467-021-25370-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 19

Abstract

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Cells in the developing embryo interpret WNT signalling with context-dependence, but the mechanism decoding these cues is unclear. Here, the authors show that combinatorial TALE/HOX activity destabilizes nucleosomes at WNT-responsive regions to activate paraxial mesodermal genes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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