Sudan Journal of Medical Sciences (Mar 2023)

BAY 11-7082: An Anti-inflammatory Drug for COVID-19

  • Mohadeseh Nemati,
  • Fahima Danesh Pouya,
  • Elmira Roshani Asl,
  • Yousef Rasmi1comma2*

DOI
https://doi.org/10.18502/sjms.v18i1.12872
Journal volume & issue
Vol. 18, no. 1
pp. 117 – 120

Abstract

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Abstract The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new coronavirus named by the International Committee on Taxonomy of Viruses. COVID-19 patients have high mortality due to respiratory failure from acute respiratory distress syndrome (ARDS) induced by SARS-CoV-2. The abnormal activation of P21-activated kinase (PAK1, RAC/CDC42-activated kinase 1) is reported in COVID-19. The PAK1 induces nuclear factor kappa B (NF-κB) activation as well as inflammatory pathways through its stimulation. BAY 11-7082 { (E) 3-[(4-methylphenyl)-sulfonyl]-2-propenenitrile is one of the therapies that inhibit inflammation via mentioned signaling pathway, therefore, we suggest that this drug can potentially be effective in treating COVID-19.

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