Blood volume and structural imaging as an early indicator for photodynamic response

Abstract

This study aims to discuss blood volume (BV), total hemoglobin concentration quantification, and ultrasound signal variations for their correlation with photodynamic therapy-induced modifications in the tumor and possibly with tumor response. The images were interpreted in the frequency domain by applying a two-dimensional fast Fourier transform to the spatial domain images. The experimental results from animals treated with verteporfin showed a significant reduction in BV.

Keywords

• Blood volume
• Total hemoglobin concentration
• Ultrasound
• Fast Fourier transform
• Verteporfin