Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones

Vu Van Vu; Trinh Thi Nhung; Nguyen Thi Thanh; Luu Van Chinh; Vu Dinh Tien; Vu Thu Thuy; Do Thi Thao; Nguyen Hai Nam; Angela Koeckritz; Tran Khac Vu

doi:10.1155/2017/3687182

Journal of Chemistry (Jan 2017)

Synthesis and Biological Evaluation of New (−)-Gossypol-Derived Schiff Bases and Hydrazones

Vu Van Vu,
Trinh Thi Nhung,
Nguyen Thi Thanh,
Luu Van Chinh,
Vu Dinh Tien,
Vu Thu Thuy,
Do Thi Thao,
Nguyen Hai Nam,
Angela Koeckritz,
Tran Khac Vu

Affiliations

Vu Van Vu: School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, Vietnam
Trinh Thi Nhung: School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, Vietnam
Nguyen Thi Thanh: School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, Vietnam
Luu Van Chinh: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Vu Dinh Tien: School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, Vietnam
Vu Thu Thuy: School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, Vietnam
Do Thi Thao: Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Nguyen Hai Nam: Hanoi University of Pharmacy (HUP), 13-15 Le Thanh Tong, Hanoi, Vietnam
Angela Koeckritz: Leibniz Institute for Catalysis at the University of Rostock, Albert-Einstein-Str. 29A, 18059 Rostock, Germany
Tran Khac Vu: School of Chemical Engineering, Hanoi University of Science and Technology, No. 1 Dai Co Viet, Hai Ba Trung, Hanoi, Vietnam

DOI: https://doi.org/10.1155/2017/3687182
Journal volume & issue: Vol. 2017

Abstract

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A series of 14 new (-)-gossypol Schiff bases and hydrazones have been synthesized via an in situ procedure in high yields. Structural data showed that all target compounds exist as the enamine tautomer. Bioassays showed that several compounds exhibited cytotoxic effects against three human cancer cell lines. Compound 8a showed the greatest cytotoxic effect against hepatocellular carcinoma (HepG2), lung carcinoma (LU-1), and breast cancer (MCF-7) cell lines with IC50 values of 20.93, 13.58, and 9.40 μM, respectively. However, in an antibacterial test, compounds 8a and 8b inhibited Staphylococcus aureus and Bacillus cereus and compound 8e inhibited only Staphylococcus aureus at the same MIC values of 1024 μg/ml.

Published in Journal of Chemistry

ISSN: 2090-9063 (Print); 2090-9071 (Online)
Publisher: Hindawi Limited
Country of publisher: United Kingdom
LCC subjects: Science: Chemistry
Website: https://www.hindawi.com/journals/jchem/

About the journal