Nature Communications (Mar 2023)
Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice
- Gen Chen,
- Ning An,
- Jingling Shen,
- Huinan Chen,
- Yunjie Chen,
- Jia Sun,
- Zhicheng Hu,
- Junhui Qiu,
- Cheng Jin,
- Shengqu He,
- Lin Mei,
- Yanru Sui,
- Wanqian Li,
- Peng Chen,
- Xueqiang Guan,
- Maoping Chu,
- Yang Wang,
- Litai Jin,
- Kwonseop Kim,
- Xiaokun Li,
- Weitao Cong,
- Xu Wang
Affiliations
- Gen Chen
- School of Pharmaceutical Science, Wenzhou Medical University
- Ning An
- Department of Pharmacy, The Affiliated Li Huili Hospital, Ningbo University
- Jingling Shen
- Institute of Life Sciences, College of Life and Environmental Sciences, Wenzhou University
- Huinan Chen
- School of Pharmaceutical Science, Wenzhou Medical University
- Yunjie Chen
- Department of Pharmacy, Ningbo First Hospital
- Jia Sun
- School of Pharmaceutical Science, Wenzhou Medical University
- Zhicheng Hu
- Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), School of Pharmaceutical Science, Wenzhou Medical University
- Junhui Qiu
- School of Pharmaceutical Science, Wenzhou Medical University
- Cheng Jin
- School of Pharmaceutical Science, Wenzhou Medical University
- Shengqu He
- School of Pharmaceutical Science, Wenzhou Medical University
- Lin Mei
- Department of Pharmacy, Xiamen Medical College
- Yanru Sui
- School of Pharmaceutical Science, Wenzhou Medical University
- Wanqian Li
- Pharmacy Department, Taizhou Municipal Hospital
- Peng Chen
- Department of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
- Xueqiang Guan
- Department of Cardiology, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
- Maoping Chu
- Pediatric Research Institute, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University
- Yang Wang
- Department of Histology and Embryology, Institute of Neuroscience, Wenzhou Medical University
- Litai Jin
- School of Pharmaceutical Science, Wenzhou Medical University
- Kwonseop Kim
- College of Pharmacy, Chonnam National University
- Xiaokun Li
- School of Pharmaceutical Science, Wenzhou Medical University
- Weitao Cong
- School of Pharmaceutical Science, Wenzhou Medical University
- Xu Wang
- School of Pharmaceutical Science, Wenzhou Medical University
- DOI
- https://doi.org/10.1038/s41467-023-36895-1
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 18
Abstract
Although the role of FGFs in cardiovascular disease has attracted extensive attention, the potential role of FGF18 in pathological cardiac hypertrophy remains unknown. Here, the authors show the cardioprotective effect of FGF18 is mediated by maintaining redox homeostasis through FYN/Nox4 signaling.
