Theoretical investigation on the effect of terahertz wave on Ca2+ transport in the calcium channel
Lianghao Guo,
Wenfei Bo,
Kaicheng Wang,
Shaomeng Wang,
Yubin Gong
Affiliations
Lianghao Guo
School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Wenfei Bo
National University of Defense Technology, Xi'an, Shaanxi 710106, China
Kaicheng Wang
School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China
Shaomeng Wang
School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China; National Key Lab on Vacuum Electronics, Medico-Engineering Cooperation on Applied Medicine Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China; Corresponding author
Yubin Gong
School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China; National Key Lab on Vacuum Electronics, Medico-Engineering Cooperation on Applied Medicine Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, China; Corresponding author
Summary: The question of whether terahertz (THz) waves can interact with ions in channels of nerve cells and cause a further reaction has attracted much attention. To answer this question, we investigate the spontaneous radiation generated by Ca2+ moving in calcium channels and the effect of THz radiation on the transport of Ca2+ by solving the mathematical physical model through Brownian dynamics (BD) simulations. It is obtained that the moving Ca2+ in a calcium channel can generate electromagnetic radiation, the corresponding spectrum of which is concentrated in the THz range. Meanwhile, both the ion number in the channel and the background temperature are proved to have significant effects on the spontaneous emission spectra. The studies also show that external THz radiation can accelerate Ca2+ transport through the ion channel. These results are expected to provide a theoretical basis for the future treatment of THz waves in the neurological field.
