Nature Communications (Feb 2023)
Genome-wide host-pathogen analyses reveal genetic interaction points in tuberculosis disease
- Jody Phelan,
- Paula Josefina Gomez-Gonzalez,
- Nuria Andreu,
- Yosuke Omae,
- Licht Toyo-Oka,
- Hideki Yanai,
- Reiko Miyahara,
- Supalert Nedsuwan,
- Paola Florez de Sessions,
- Susana Campino,
- Neneh Sallah,
- Julian Parkhill,
- Nat Smittipat,
- Prasit Palittapongarnpim,
- Taisei Mushiroda,
- Michiaki Kubo,
- Katsushi Tokunaga,
- Surakameth Mahasirimongkol,
- Martin L. Hibberd,
- Taane G. Clark
Affiliations
- Jody Phelan
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Paula Josefina Gomez-Gonzalez
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Nuria Andreu
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Yosuke Omae
- Department of Human Genetics, Graduate School of Medicine, The University of Tokyo
- Licht Toyo-Oka
- Department of Human Genetics, Graduate School of Medicine, The University of Tokyo
- Hideki Yanai
- Fukujuji Hospital and Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association
- Reiko Miyahara
- Genome Medical Science Project, National Center for Global Health and Medicine
- Supalert Nedsuwan
- Chiangrai Prachanukroh Hospital
- Paola Florez de Sessions
- Genome Institute of Singapore
- Susana Campino
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Neneh Sallah
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Julian Parkhill
- Department of Veterinary Medicine, University of Cambridge
- Nat Smittipat
- National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency
- Prasit Palittapongarnpim
- National Center for Genetic Engineering and Biotechnology, National Science and Technology Development Agency
- Taisei Mushiroda
- RIKEN Center for Integrative Medical Sciences
- Michiaki Kubo
- RIKEN Center for Integrative Medical Sciences
- Katsushi Tokunaga
- Department of Human Genetics, Graduate School of Medicine, The University of Tokyo
- Surakameth Mahasirimongkol
- Medical Genetics Center, Medical Life Sciences Institute, Department of Medical Sciences, Ministry of Public Health
- Martin L. Hibberd
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- Taane G. Clark
- Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
- DOI
- https://doi.org/10.1038/s41467-023-36282-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 7
Abstract
Few genetic loci have been associated with tuberculosis infection, possibly because of the influence of genetic variation in the pathogen. Here, the authors integrate human and Mycobacterium tuberculosis genetics to find genome-genome interactions associated with infection.
