Diabetes, Metabolic Syndrome and Obesity (Feb 2024)

Uric Acid Metabolic Disorders in Pituitary-Target Gland Axis

  • Li R,
  • Wu B,
  • Han M,
  • Li M,
  • Yang X,
  • Zhang J,
  • Zhang Y,
  • Liu Y

Journal volume & issue
Vol. Volume 17
pp. 661 – 673

Abstract

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Ru Li,1,2,* Baofeng Wu,1,2,* Minmin Han,1,2 Mengnan Li,1,2 Xifeng Yang,1,2 Jian Zhang,1,2 Yi Zhang,3 Yunfeng Liu1 1Department of Endocrinology, The First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2The First Clinical Medical College, Shanxi Medical University, Taiyuan, People’s Republic of China; 3Department of Pharmacology, Shanxi Medical University, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yunfeng Liu, Department of Endocrinology, The First Hospital of Shanxi Medical University, 85 Jiefang South Road, Taiyuan, People’s Republic of China, Tel +86 18703416196, Email [email protected] Yi Zhang, Department of Pharmacology, Shanxi Medical University, Taiyuan, People’s Republic of China, Email [email protected]: Uric acid (UA) is the end product of purine metabolism in the human, and the imbalance between production and excretion results in the disturbance of serum uric acid (SUA). There is evidence suggesting that pituitary-target gland hormones can affect UA metabolism through regulating the activity of xanthine oxidase and UA transporters. Related endocrine diseases including thyroid dysfunction, polycystic ovary syndrome, acromegaly and Cushing’s syndrome are often accompanied by elevated UA levels. In addition to the direct influence of abnormal hormones, obesity and insulin resistant play a pivotal role. Diabetes insipidus and the syndrome of inappropriate antidiuretic hormone secretion also present with abnormal SUA levels due to the action of antidiuretic hormone. However, certain evidence within the population is disputed. This review summarized the effects of pituitary-target gland hormones on UA metabolism, and preliminarily described the related mechanisms, offering a theoretical foundation for assessing SUA in endocrine disorders as well as guiding its management.Keywords: uric acid, hyperuricemia, pituitary-target gland, endocrine disease, insulin resistant

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