Artificial Ribonucleases

Abstract

Chemically modified oligonucleotides serve as tools in fundamental research as diagnostic reagents and pharmaceutical compounds. Various chemical groups can nowadays be linked to oligonucleotides, In particular, synthetic constructs of oligonucleotides and lanthanide complexes can serve as artificial ribonucleases. In this paper, some applications of modified oligonucleotides originating from our research efforts directed at the development of artificial ribonucleases are summarized.

Keywords

• Artificial ribonucleases
• Lanthanide complexes
• Oligonucleotide
• Rna
• Rna cleavage