Methylation of the Vitamin D Receptor Gene in Human Disorders

Beatrice Gasperini; Angela Falvino; Eleonora Piccirilli; Umberto Tarantino; Annalisa Botta; Virginia Veronica Visconti

doi:10.3390/ijms25010107

International Journal of Molecular Sciences (Dec 2023)

Methylation of the Vitamin D Receptor Gene in Human Disorders

Beatrice Gasperini,
Angela Falvino,
Eleonora Piccirilli,
Umberto Tarantino,
Annalisa Botta,
Virginia Veronica Visconti

Affiliations

Beatrice Gasperini: Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
Angela Falvino: Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
Eleonora Piccirilli: Department of Clinical Sciences and Translational Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
Umberto Tarantino: Department of Clinical Sciences and Translational Medicine, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
Annalisa Botta: Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
Virginia Veronica Visconti: Department of Biomedicine and Prevention, University of Rome “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy

DOI: https://doi.org/10.3390/ijms25010107
Journal volume & issue: Vol. 25, no. 1
p. 107

Abstract

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The Vitamin D Receptor (VDR) mediates the actions of 1,25-Dihydroxvitamin D3 (1,25(OH)2D3), which has important roles in bone homeostasis, growth/differentiation of cells, immune functions, and reduction of inflammation. Emerging evidences suggest that epigenetic modifications of the VDR gene, particularly DNA methylation, may contribute to the onset and progression of many human disorders. This review aims to summarize the available information on the role of VDR methylation signatures in different pathological contexts, including autoimmune diseases, infectious diseases, cancer, and others. The reversible nature of DNA methylation could enable the development of therapeutic strategies, offering new avenues for the management of these worldwide diseases.

Published in International Journal of Molecular Sciences

ISSN: 1661-6596 (Print); 1422-0067 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General); Science: Chemistry
Website: http://www.mdpi.com/journal/ijms

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