Frontiers in Oncology (Oct 2023)

Temporal changes in treatment patterns by age group and functional status before and after PD-1/L1 inhibitor approvals in advanced urothelial carcinoma

  • Gurjyot K. Doshi,
  • Haojie Li,
  • Mehmet Burcu,
  • Srinivas Annavarapu,
  • Karen Wells,
  • Kentaro Imai,
  • Blanca Homet Moreno,
  • Puneet Singhal,
  • Ronac Mamtani

DOI
https://doi.org/10.3389/fonc.2023.1210208
Journal volume & issue
Vol. 13

Abstract

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IntroductionMetastatic urothelial carcinoma (mUC) has poor prognosis. A high unmet need exists for novel treatment for those who are unfit for platinum-based chemotherapy.MethodsWe aimed to describe real-world temporal changes in patient characteristics and 1L treatment selection for mUC patients in the United States following the approval of anti-PD-1/L1 treatments. This study was a retrospective, observational study using anonymized and structured oncology electronic medical record (EMR) data from IQVIA and the US Oncology Network iKnowMed (USON).ResultsAfter approval of 1L anti-PD-1/L1 treatment for mUC, there is a marked increase in the use of 1L anti-PD-1/L1 monotherapies, accompanied by a proportional decrease in 1L platinum-based treatments and non-guideline-based therapy; particularly among the elderly (> 75 years) and those with poor ECOG performance status (ECOG PS 2+).DiscussionAnti-PD-1/L1 monotherapies fulfill the prior unmet need of frail mUC patients who are ineligible for platinum-based therapies.

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