Deuterium metabolic imaging in the human brain at 9.4 Tesla with high spatial and temporal resolution
Loreen Ruhm,
Nikolai Avdievich,
Theresia Ziegs,
Armin M. Nagel,
Henk M. De Feyter,
Robin A. de Graaf,
Anke Henning
Affiliations
Loreen Ruhm
High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University of Tübingen, Germany; Corresponding author.
Nikolai Avdievich
High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany
Theresia Ziegs
High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University of Tübingen, Germany
Armin M. Nagel
Institute of Radiology, University Hospital Erlangen, Erlangen, Germany; Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Henk M. De Feyter
Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States
Robin A. de Graaf
Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States
Anke Henning
High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tübingen, Germany; Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas/Texas, United States
Purpose: To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and a fast chemical shift imaging (CSI) sequence at an ultrahigh field strength of B0 = 9.4 T. 2H metabolic measurements with a temporal resolution of 10 min enabled the investigation of the glucose metabolism in healthy human subjects. Methods: The study was performed with a double-tuned coil with 10 TxRx channels for 1H and 8TxRx/2Rx channels for 2H and an Ernst angle 3D CSI sequence with a nominal spatial resolution of 2.97 ml and a temporal resolution of 10 min. Results: The metabolism of [6,6′-2H2]-labeled glucose due to the TCA cycle could be made visible in high resolution metabolite images of deuterated water, glucose and Glx over the entire human brain. Conclusion: X-nuclei MRSI as DMI can highly benefit from ultrahigh field strength enabling higher temporal and spatial resolutions.
