Frontiers in Aging Neuroscience (Nov 2016)

Neurochemical and Neuroanatomical Plasticity Following Memory Training and Yoga Interventions in Older Adults with Mild Cognitive Impairment

  • Hongyu Yang,
  • Amber M Leaver,
  • Prabha Siddarth,
  • Pattharee Paholpak,
  • Pattharee Paholpak,
  • Linda Ercoli,
  • Natalie St. Cyr,
  • Harris Anthony Eyre,
  • Harris Anthony Eyre,
  • Harris Anthony Eyre,
  • Harris Anthony Eyre,
  • Katherine L Narr,
  • Dharma S Khalsa,
  • Helen Lavretsky

DOI
https://doi.org/10.3389/fnagi.2016.00277
Journal volume & issue
Vol. 8

Abstract

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Behavioral interventions are becoming increasingly popular approaches to ameliorate age-related cognitive decline, but their underlying neurobiological mechanisms and clinical efficiency have not been fully elucidated. The present study explored brain plasticity associated with two behavioral interventions, memory enhancement training (MET) and a mind-body practice (yogic meditation), in healthy seniors with mild cognitive impairment (MCI) using structural magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (1H-MRS). Senior participants (age ≥ 55 years) with MCI were randomized to the MET or yogic meditation interventions. For both interventions, participants completed either MET training or Kundalini yoga for 60-min sessions over 12 weeks, with 12-min daily homework assignments. Gray matter volume and metabolite concentrations in the dorsal anterior cingulate cortex (dACC) and bilateral hippocampus were measured by structural MRI and 1H-MRS at baseline and after 12 weeks of training. Metabolites measured included glutamate-glutamine (Glx), choline-containing compounds (Cho, including glycerophosphocholine and phosphocholine), gamma-aminobutyric acid (GABA), and N-acetyl aspartate and N-acetylaspartyl-glutamate (NAA-NAAG). In total, 11 participants completed MET and 14 completed yogic meditation for this study. Structural MRI analysis showed an interaction between time and group in dACC, indicating a trend towards increased gray matter volume after the MET intervention. 1H-MRS analysis showed an interaction between time and group in choline-containing compounds in bilateral hippocampus, induced by significant decreases after the MET intervention. Though preliminary, our results suggest that memory training induces structural and neurochemical plasticity in seniors with mild cognitive impairment. Further research is needed to determine whether mind-body interventions like yoga yield similar neuroplastic changes.

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