An oxygen-sensitive toxin–antitoxin system

Oriol Marimon; João M. C. Teixeira; Tiago N. Cordeiro; Valerie W. C. Soo; Thammajun L. Wood; Maxim Mayzel; Irene Amata; Jesús García; Ainara Morera; Marina Gay; Marta Vilaseca; Vladislav Yu Orekhov; Thomas K. Wood; Miquel Pons

doi:10.1038/ncomms13634

Nature Communications (Dec 2016)

An oxygen-sensitive toxin–antitoxin system

Oriol Marimon,
João M. C. Teixeira,
Tiago N. Cordeiro,
Valerie W. C. Soo,
Thammajun L. Wood,
Maxim Mayzel,
Irene Amata,
Jesús García,
Ainara Morera,
Marina Gay,
Marta Vilaseca,
Vladislav Yu Orekhov,
Thomas K. Wood,
Miquel Pons

Affiliations

Oriol Marimon: Inorganic and Organic Chemistry Department, Biomolecular NMR Laboratory, Organic Chemistry Section, University of Barcelona
João M. C. Teixeira: Inorganic and Organic Chemistry Department, Biomolecular NMR Laboratory, Organic Chemistry Section, University of Barcelona
Tiago N. Cordeiro: Inorganic and Organic Chemistry Department, Biomolecular NMR Laboratory, Organic Chemistry Section, University of Barcelona
Valerie W. C. Soo: Department of Chemical Engineering and Department of Biochemistry and Molecular Biology, Pennsylvania State University
Thammajun L. Wood: Department of Chemical Engineering and Department of Biochemistry and Molecular Biology, Pennsylvania State University
Maxim Mayzel: Swedish NMR Centre, Gothenburg University
Irene Amata: Inorganic and Organic Chemistry Department, Biomolecular NMR Laboratory, Organic Chemistry Section, University of Barcelona
Jesús García: Inorganic and Organic Chemistry Department, Biomolecular NMR Laboratory, Organic Chemistry Section, University of Barcelona
Ainara Morera: Inorganic and Organic Chemistry Department, Biomolecular NMR Laboratory, Organic Chemistry Section, University of Barcelona
Marina Gay: Institute for Research in Biomedicine (IRB-Barcelona), The Barcelona Institute of Science and Technology
Marta Vilaseca: Institute for Research in Biomedicine (IRB-Barcelona), The Barcelona Institute of Science and Technology
Vladislav Yu Orekhov: Swedish NMR Centre, Gothenburg University
Thomas K. Wood: Department of Chemical Engineering and Department of Biochemistry and Molecular Biology, Pennsylvania State University
Miquel Pons: Inorganic and Organic Chemistry Department, Biomolecular NMR Laboratory, Organic Chemistry Section, University of Barcelona

DOI: https://doi.org/10.1038/ncomms13634
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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Classical toxin–antitoxin systems in bacteria are based on silencing of a toxin by an antitoxin that, when inactivated, releases the toxin, resulting in a change in metabolism. Here, the authors characterize an oxygen-sensitive toxin–antitoxin system and discuss the implications for the role of the Hha antitoxin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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