The lack of causal link between myopia and intraocular pressure: Insights from cross-sectional analysis and Mendelian randomization study

Abstract

Objective: This study aimed to explore the potential causal relationship between intraocular pressure (IOP) and myopia. Methods: The study included 3,459 patients who underwent corneal refractive surgery at our institution between 2021 and 2023. Preoperative data on IOP, spherical equivalent (SE), axial length (AL), and corneal thickness (CCT) were collected. The association between IOP and myopia was investigated through rank correlation analysis, and causal inference was examined using Mendelian randomization (MR) methods, including MR-Egger, weighted median, mode-based estimation, simple mode, and inverse variance weighted (IVW) approaches. Utilizing summary statistics from genome-wide association studies (GWAS), IOP was considered as the exposure, with myopia as the outcome variable. IVW method was employed for the primary analysis, supplemented by sensitivity analyses. Results: Cross-sectional analysis revealed a non-significant association between corrected IOP (cIOP) and myopia (r = -0.019, P = 0.12). MR analysis indicated a non-significant genetic causal relationship between cIOP and myopia under the IVW method (OR = 1.001; 95 % CI [0.999–1.003], P = 0.22), a finding corroborated in replication samples (OR = 0.98; 95 % CI [0.96–1.00], P = 0.099). Conclusion: This study did not find a direct causal link between IOP and the development of myopia. These findings challenge the traditional role attributed to IOP in the progression of myopia and highlight the complex, multifactorial process of myopia development. This provides a new perspective on understanding the intricate mechanisms behind myopia progression.

Keywords

• Intraocular pressure
• Myopia
• Cross-sectional analysis
• Mendelian randomization
• Genetic causality