Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease

Tianhao Zhou; Debjyoti Kundu; Jonathan Robles-Linares; Vik Meadows; Keisaku Sato; Leonardo Baiocchi; Burcin Ekser; Shannon Glaser; Gianfranco Alpini; Heather Francis; Lindsey Kennedy

doi:10.3390/cells10082072

Cells (Aug 2021)

Feedback Signaling between Cholangiopathies, Ductular Reaction, and Non-Alcoholic Fatty Liver Disease

Tianhao Zhou,
Debjyoti Kundu,
Jonathan Robles-Linares,
Vik Meadows,
Keisaku Sato,
Leonardo Baiocchi,
Burcin Ekser,
Shannon Glaser,
Gianfranco Alpini,
Heather Francis,
Lindsey Kennedy

Affiliations

Tianhao Zhou: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Debjyoti Kundu: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Jonathan Robles-Linares: Department of Graduate Studies, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Vik Meadows: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Keisaku Sato: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Leonardo Baiocchi: Liver Unit, Department of Medicine, University of Rome Tor Vergata, 00133 Rome, Italy
Burcin Ekser: Division of Transplant Surgery, Department of Surgery, Indiana University, Indianapolis, IN 46202, USA
Shannon Glaser: Department of Medical Physiology, Texas A&M University College of Medicine Bryan, Bryan, TX 77807, USA
Gianfranco Alpini: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Heather Francis: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Lindsey Kennedy: Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA

DOI: https://doi.org/10.3390/cells10082072
Journal volume & issue: Vol. 10, no. 8
p. 2072

Abstract

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Fatty liver diseases, such as non-alcoholic fatty liver disease (NAFLD), are global health disparities, particularly in the United States, as a result of cultural eating habits and lifestyle. Pathological studies on NAFLD have been mostly focused on hepatocytes and other inflammatory cell types; however, the impact of other biliary epithelial cells (i.e., cholangiocytes) in the promotion of NAFLD is growing. This review article will discuss how cholestatic injury and cholangiocyte activity/ductular reaction influence NAFLD progression. Furthermore, this review will provide informative details regarding the fundamental properties of cholangiocytes and bile acid signaling that can influence NAFLD. Lastly, studies relating to the pathogenesis of NAFLD, cholangiopathies, and ductular reaction will be analyzed to help gain insight for potential therapies.

Published in Cells

ISSN: 2073-4409 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General): Cytology
Website: https://www.mdpi.com/journal/cells

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Abstract

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