Nature Communications (Jan 2020)

Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway

  • Dan He,
  • Hongguang Wu,
  • Jinnan Xiang,
  • Xinsen Ruan,
  • Peike Peng,
  • Yuanyuan Ruan,
  • Ye-Guang Chen,
  • Yibin Wang,
  • Qiang Yu,
  • Hongbing Zhang,
  • Samy L. Habib,
  • Ronald A. De Pinho,
  • Huijuan Liu,
  • Baojie Li

DOI
https://doi.org/10.1038/s41467-019-13911-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Intestinal aging is associated with declines in structure and absorption of nutrients. Here, the authors show that aging related intestinal decline is mediated by activation of the mTORC1-p38MAPK-p53 pathway in intestinal stem cells and can be ameliorated by abrogating mTORC1 or p38MAPK activity.