iScience (Oct 2023)

Remnant cholesterol but not LDL cholesterol is associated with 5-year bleeding following percutaneous coronary intervention

  • Jiawen Li,
  • Yulong Li,
  • Pei Zhu,
  • Jingjing Xu,
  • Xiaofang Tang,
  • Shubin Qiao,
  • Weixian Yang,
  • Yuejin Yang,
  • Runlin Gao,
  • Jinqing Yuan,
  • Xueyan Zhao

Journal volume & issue
Vol. 26, no. 10
p. 107666

Abstract

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Summary: This study was aimed to investigate the association between remnant cholesterol (RC) and low-density lipoprotein cholesterol (LDL-C) concentrations and long-term bleeding. A total of 10,724 consecutive patients who underwent percutaneous coronary intervention in 2013 were prospectively enrolled. During a median follow-up of 5.1 years, 411 bleeding events and 42 intracranial hemorrhages (ICH) were recorded. The findings revealed that lower RC concentrations were independently associated with an increased risk of long-term bleeding events (continuous RC hazard ratio [HR]: 0.47, 95% confidence interval [CI]: 0.26–0.85; Q4 vs. Q1 HR: 0.66, 95% CI: 0.45–0.98), whereas lower LDL-C concentrations did not show a similar association. Additionally, a non-linear relationship was observed between RC concentrations and the risk of ICH (P for non-linear trend = 0.014), but no such relationship was found for LDL-C concentrations. These results provided insights into the safety of LDL-C-lowering therapy and emphasized the significance of RC concentrations in lipid management.

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