Nature Communications (Dec 2021)
Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19
- Masako Nishikawa,
- Hiroshi Kanno,
- Yuqi Zhou,
- Ting-Hui Xiao,
- Takuma Suzuki,
- Yuma Ibayashi,
- Jeffrey Harmon,
- Shigekazu Takizawa,
- Kotaro Hiramatsu,
- Nao Nitta,
- Risako Kameyama,
- Walker Peterson,
- Jun Takiguchi,
- Mohammad Shifat-E-Rabbi,
- Yan Zhuang,
- Xuwang Yin,
- Abu Hasnat Mohammad Rubaiyat,
- Yunjie Deng,
- Hongqian Zhang,
- Shigeki Miyata,
- Gustavo K. Rohde,
- Wataru Iwasaki,
- Yutaka Yatomi,
- Keisuke Goda
Affiliations
- Masako Nishikawa
- Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
- Hiroshi Kanno
- Department of Chemistry, The University of Tokyo
- Yuqi Zhou
- Department of Chemistry, The University of Tokyo
- Ting-Hui Xiao
- Department of Chemistry, The University of Tokyo
- Takuma Suzuki
- Department of Computational Biology and Medical Sciences, The University of Tokyo
- Yuma Ibayashi
- Department of Chemistry, The University of Tokyo
- Jeffrey Harmon
- Department of Chemistry, The University of Tokyo
- Shigekazu Takizawa
- Department of Chemistry, The University of Tokyo
- Kotaro Hiramatsu
- Department of Chemistry, The University of Tokyo
- Nao Nitta
- CYBO, Inc
- Risako Kameyama
- Department of Chemistry, The University of Tokyo
- Walker Peterson
- Department of Chemistry, The University of Tokyo
- Jun Takiguchi
- Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
- Mohammad Shifat-E-Rabbi
- Department of Biomedical Engineering, University of Virginia
- Yan Zhuang
- Department of Electrical and Computer Engineering, University of Virginia
- Xuwang Yin
- Department of Electrical and Computer Engineering, University of Virginia
- Abu Hasnat Mohammad Rubaiyat
- Department of Electrical and Computer Engineering, University of Virginia
- Yunjie Deng
- Department of Chemistry, The University of Tokyo
- Hongqian Zhang
- Department of Chemistry, The University of Tokyo
- Shigeki Miyata
- Research and Development Department, Central Blood Institute, Japanese Red Cross Society
- Gustavo K. Rohde
- Department of Biomedical Engineering, University of Virginia
- Wataru Iwasaki
- Department of Computational Biology and Medical Sciences, The University of Tokyo
- Yutaka Yatomi
- Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
- Keisuke Goda
- Department of Chemistry, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-021-27378-2
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 12
Abstract
The authors report the landscape of circulating platelet aggregates in COVID-19 obtained by massive single-cell image-based profiling and temporal monitoring to elucidate the underlying process of COVID-19-assocaited microvascular thrombosis.
