Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya

Yoseph Atilaw; Lois Muiva-Mutisya; Albert Ndakala; Hoseah M. Akala; Redemptah Yeda; Yu J. Wu; Paolo Coghi; Vincent K. W. Wong; Máté Erdélyi; Abiy Yenesew

doi:10.3390/molecules22091514

Molecules (Sep 2017)

Four Prenylflavone Derivatives with Antiplasmodial Activities from the Stem of Tephrosia purpurea subsp. leptostachya

Yoseph Atilaw,
Lois Muiva-Mutisya,
Albert Ndakala,
Hoseah M. Akala,
Redemptah Yeda,
Yu J. Wu,
Paolo Coghi,
Vincent K. W. Wong,
Máté Erdélyi,
Abiy Yenesew

Affiliations

Yoseph Atilaw: Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya
Lois Muiva-Mutisya: Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya
Albert Ndakala: Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya
Hoseah M. Akala: Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI)—Walter Reed Project, Kisumu and Nairobi, P.O. Box 54-40100, Kisumu, Kenya
Redemptah Yeda: Global Emerging Infections Surveillance (GEIS) Program, United States Army Medical Research Unit-Kenya (USAMRU-K), Kenya Medical Research Institute (KEMRI)—Walter Reed Project, Kisumu and Nairobi, P.O. Box 54-40100, Kisumu, Kenya
Yu J. Wu: State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, P.O. Box 999078, China
Paolo Coghi: State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, P.O. Box 999078, China
Vincent K. W. Wong: State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau, P.O. Box 999078, China
Máté Erdélyi: Department of Chemistry and Molecular Biology, University of Gothenburg, SE-40530 Gothenburg, Sweden
Abiy Yenesew: Department of Chemistry, University of Nairobi, Nairobi, P.O. Box 30197-00100, Kenya

DOI: https://doi.org/10.3390/molecules22091514
Journal volume & issue: Vol. 22, no. 9
p. 1514

Abstract

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Four new flavones with modified prenyl groups, namely (E)-5-hydroxytephrostachin (1), purleptone (2), (E)-5-hydroxyanhydrotephrostachin (3), and terpurlepflavone (4), along with seven known compounds (5–11), were isolated from the CH2Cl2/MeOH (1:1) extract of the stem of Tephrosia purpurea subsp. leptostachya, a widely used medicinal plant. Their structures were elucidated on the basis of NMR spectroscopic and mass spectrometric evidence. Some of the isolated compounds showed antiplasmodial activity against the chloroquine-sensitive D6 strains of Plasmodium falciparum, with (E)-5-hydroxytephrostachin (1) being the most active, IC50 1.7 ± 0.1 μM, with relatively low cytotoxicity, IC50 > 21 μM, against four cell-lines.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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