Frontiers in Immunology (Jul 2024)
Protocol of a prospective multicenter study on comorbidity impact on multiple sclerosis and antibody-mediated diseases of the central nervous system (COMMIT)
- Sara Samadzadeh,
- Sara Samadzadeh,
- Sara Samadzadeh,
- Rafl Adnan,
- Rafl Adnan,
- Paulina Berglova,
- Mahdi Barzegar,
- Birgit Debrabant,
- Stine Gundtoft Roikjaer,
- Stine Gundtoft Roikjaer,
- Stine Gundtoft Roikjaer,
- Michael Levy,
- Axel Petzold,
- Axel Petzold,
- Axel Petzold,
- Jacqueline Palace,
- Eoin P. Flanagan,
- Sara Mariotto,
- Soeren T. Skou,
- Soeren T. Skou,
- Anne Froelich,
- Anne Froelich,
- Anne Froelich,
- Itay Lotan,
- Itay Lotan,
- Silvia Messina,
- Ruth Geraldes,
- Susanna Asseyer,
- Susanna Asseyer,
- Susanna Asseyer,
- Susanna Asseyer,
- Hadas Stiebel-Kalish,
- Hadas Stiebel-Kalish,
- Hadas Stiebel-Kalish,
- Frederike Cosima Oertel,
- Frederike Cosima Oertel,
- Frederike Cosima Oertel,
- Frederike Cosima Oertel,
- Vahid Shaygannejad,
- Mohammad Ali Sahraian,
- Ho Jin Kim,
- Jeffrey L. Bennett,
- Chotima Böttcher,
- Chotima Böttcher,
- Chotima Böttcher,
- Hanna G. Zimmermann,
- Hanna G. Zimmermann,
- Hanna G. Zimmermann,
- Hanna G. Zimmermann,
- Hanna G. Zimmermann,
- Brian G. Weinshenker,
- Friedemann Paul,
- Friedemann Paul,
- Friedemann Paul,
- Friedemann Paul,
- Nasrin Asgari,
- Nasrin Asgari,
- Nasrin Asgari
Affiliations
- Sara Samadzadeh
- Institute of Regional Health Research and, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Sara Samadzadeh
- The Center for Neurological Research, Department of Neurology Slagelse Hospital, Slagelse, Denmark
- Sara Samadzadeh
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany
- Rafl Adnan
- Institute of Regional Health Research and, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Rafl Adnan
- The Center for Neurological Research, Department of Neurology Slagelse Hospital, Slagelse, Denmark
- Paulina Berglova
- The Center for Neurological Research, Department of Neurology Slagelse Hospital, Slagelse, Denmark
- Mahdi Barzegar
- Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
- Birgit Debrabant
- Department of Mathematics and Computer Science, Faculty of Natural Sciences, University of Southern Denmark, Odense, Denmark
- Stine Gundtoft Roikjaer
- Institute of Regional Health Research and, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Stine Gundtoft Roikjaer
- The Center for Neurological Research, Department of Neurology Slagelse Hospital, Slagelse, Denmark
- Stine Gundtoft Roikjaer
- The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Slagelse, Region Zealand, Denmark
- Michael Levy
- Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States
- Axel Petzold
- The National Hospital for Neurology and Neurosurgery, and Moorfields Eye Hospital and Queen Square University College London (UCL), Institute of Neurology, London, United Kingdom
- Axel Petzold
- Department of Neurology, Amsterdam The University Medical Center Utrecht (UMC), Amsterdam, Netherlands
- Axel Petzold
- 0Department of Ophthalmology, Amsterdam The University Medical Center Utrecht (UMC), Amsterdam, Netherlands
- Jacqueline Palace
- 1Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, National Health Service Trust, Oxford, United Kingdom
- Eoin P. Flanagan
- 2Department Neurology and Center for Multiple Sclerosis (MS), and Autoimmune Neurology, Mayo Clinic, Rochester, MN, United States
- Sara Mariotto
- 3Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Verona, Italy
- Soeren T. Skou
- The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Næstved-Slagelse-Ringsted Hospitals, Slagelse, Region Zealand, Denmark
- Soeren T. Skou
- 4Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
- Anne Froelich
- The Center for Neurological Research, Department of Neurology Slagelse Hospital, Slagelse, Denmark
- Anne Froelich
- 5Innovation and Research Centre for Multimorbidity, Slagelse Hospital, Slagelse, Denmark
- Anne Froelich
- 6Section of General Practice, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- Itay Lotan
- 7Department of Neurology and Neuroimmunology Unit, Rabin Medical Center, Petah Tikva, Israel
- Itay Lotan
- 8Tel Aviv University Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
- Silvia Messina
- 1Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, National Health Service Trust, Oxford, United Kingdom
- Ruth Geraldes
- 1Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, National Health Service Trust, Oxford, United Kingdom
- Susanna Asseyer
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany
- Susanna Asseyer
- 9Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Berlin, Germany
- Susanna Asseyer
- 0Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
- Susanna Asseyer
- 1NeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
- Hadas Stiebel-Kalish
- 8Tel Aviv University Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
- Hadas Stiebel-Kalish
- 2Department of Ophthalmology, Neuro-Ophthalmology Unit, Rabin Medical Center, Petah Tikva, Israel
- Hadas Stiebel-Kalish
- 3Eye Laboratory, Felsenstein Research Institute, Tel Aviv, Israel
- Frederike Cosima Oertel
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany
- Frederike Cosima Oertel
- 9Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Berlin, Germany
- Frederike Cosima Oertel
- 0Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
- Frederike Cosima Oertel
- 1NeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
- Vahid Shaygannejad
- Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
- Mohammad Ali Sahraian
- 4Multiple Sclerosis (MS) Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
- Ho Jin Kim
- 5Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Republic of Korea
- Jeffrey L. Bennett
- 6Department of Neurology and Ophthalmology, Programs in Neuroscience and Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO, United States
- Chotima Böttcher
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany
- Chotima Böttcher
- 9Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Berlin, Germany
- Chotima Böttcher
- 0Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
- Hanna G. Zimmermann
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany
- Hanna G. Zimmermann
- 9Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Berlin, Germany
- Hanna G. Zimmermann
- 0Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
- Hanna G. Zimmermann
- 1NeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
- Hanna G. Zimmermann
- 7Einstein Center Digital Future, Berlin, Germany
- Brian G. Weinshenker
- 8Department of Neurology, University of Virginia, Charlottesville, VA, United States
- Friedemann Paul
- Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Experimental and Clinical Research Center, Berlin, Germany
- Friedemann Paul
- 9Experimental and Clinical Research Center, a cooperation between the Max Delbrück Center for Molecular Medicine in the Helmholtz Association and Charité Universitätsmedizin Berlin, Berlin, Germany
- Friedemann Paul
- 0Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
- Friedemann Paul
- 1NeuroCure Clinical Research Center, Charité – Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
- Nasrin Asgari
- Institute of Regional Health Research and, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark
- Nasrin Asgari
- The Center for Neurological Research, Department of Neurology Slagelse Hospital, Slagelse, Denmark
- Nasrin Asgari
- 9Open Patient data Explorative Network, Odense University Hospital, University of Southern Denmark, Odense, Denmark
- DOI
- https://doi.org/10.3389/fimmu.2024.1380025
- Journal volume & issue
-
Vol. 15
Abstract
Comorbidities in patients with multiple sclerosis (MS) and antibody-mediated diseases of the central nervous system (CNS) including neuromyelitis optica spectrum disorder (NMOSD), and myelin oligodendrocyte glycoprotein (MOG)-antibody-associated disease (MOGAD) are common and may influence the course of their neurological disease. Comorbidity may contribute to neuronal injury and therefore limit recovery from attacks, accelerate disease progression, and increase disability. This study aims to explore the impact of comorbidity, particularly vascular comorbidity, and related risk factors on clinical and paraclinical parameters of MS, NMOSD and MOGAD. We propose COMMIT, a prospective multicenter study with longitudinal follow-up of patients with MS, NMOSD, and MOGAD, with or without comorbidities, as well as healthy subjects as controls. Subjects will be stratified by age, sex and ethnicity. In consecutive samples we will analyze levels of inflammation and neurodegeneration markers in both fluid and cellular compartments of the peripheral blood and cerebrospinal fluid (CSF) using multiple state-of-the-art technologies, including untargeted proteomics and targeted ultrasensitive ELISA assays and quantitative reverse transcription polymerase chain reaction (RT-qPCR) as well as high-dimensional single-cell technologies i.e., mass cytometry and single-cell RNA sequencing. Algorithm-based data analyses will be used to unravel the relationship between these markers, optical coherence tomography (OCT) and magnetic resonance imaging (MRI), and clinical outcomes including frequency and severity of relapses, long-term disability, and quality of life. The goal is to evaluate the impact of comorbidities on MS, NMOSD, and MOGAD which may lead to development of treatment approaches to improve outcomes of inflammatory demyelinating diseases of the CNS.
Keywords
- multiple sclerosis
- neuromyelitis optica spectrum disorder
- myelin oligodendrocyte glycoprotein antibody-associated disease
- antibody-mediated diseases of the central nervous system
- comorbidity
