Frontiers in Veterinary Science (Jul 2022)
Same Dosages of rPRV/XJ5-gI−/gE−/TK− Prototype Vaccine or Bartha-K61 Vaccine Similarly Protects Growing Pigs Against Lethal Challenge of Emerging vPRV/XJ-5 Strain
- Qinghai Ren,
- Qinghai Ren,
- Qinghai Ren,
- Qinghai Ren,
- Lin Li,
- Lin Li,
- Lin Li,
- Lin Li,
- Haochun Pan,
- Haochun Pan,
- Haochun Pan,
- Haochun Pan,
- Xiaobo Wang,
- Xiaobo Wang,
- Xiaobo Wang,
- Xiaobo Wang,
- Qingqing Gao,
- Qingqing Gao,
- Qingqing Gao,
- Qingqing Gao,
- Changchao Huan,
- Changchao Huan,
- Changchao Huan,
- Changchao Huan,
- Jin Wang,
- Jin Wang,
- Jin Wang,
- Jin Wang,
- Wei Zhang,
- Wei Zhang,
- Wei Zhang,
- Wei Zhang,
- Luyao Jiang,
- Luyao Jiang,
- Luyao Jiang,
- Luyao Jiang,
- Song Gao,
- Song Gao,
- Song Gao,
- Song Gao,
- Yan Kai,
- Changhai Chen
Affiliations
- Qinghai Ren
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Qinghai Ren
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Qinghai Ren
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Qinghai Ren
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Lin Li
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Lin Li
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Lin Li
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Lin Li
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Haochun Pan
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Haochun Pan
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Haochun Pan
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Haochun Pan
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Xiaobo Wang
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Xiaobo Wang
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Xiaobo Wang
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Xiaobo Wang
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Qingqing Gao
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Qingqing Gao
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Qingqing Gao
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Qingqing Gao
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Changchao Huan
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Changchao Huan
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Changchao Huan
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Changchao Huan
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Jin Wang
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Jin Wang
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Jin Wang
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Jin Wang
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Wei Zhang
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Wei Zhang
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Wei Zhang
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Wei Zhang
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Luyao Jiang
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Luyao Jiang
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Luyao Jiang
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Luyao Jiang
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Song Gao
- Key Laboratory of Avian Bioproducts Development, Ministry of Agriculture and Rural Affairs, Yangzhou University, Yangzhou, China
- Song Gao
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou, China
- Song Gao
- Institutes of Agricultural Science and Technology Development, Yangzhou University, Yangzhou, China
- Song Gao
- College of Veterinary Medicine, Yangzhou University, Yangzhou, China
- Yan Kai
- Jiangsu Provincial Center for Animal Disease Control and Prevention, Nanjing, China
- Changhai Chen
- Jiangsu Provincial Center for Animal Disease Control and Prevention, Nanjing, China
- DOI
- https://doi.org/10.3389/fvets.2022.896689
- Journal volume & issue
-
Vol. 9
Abstract
Variant pseudorabies viruses (vPRV) have constantly emerged in China since late 2011. In the present study, a 1 × 106.0 TCID50 per-animal dosage of a commercially available Bartha-K61 vaccine and an rPRV/XJ5-gI−/gE−/TK− prototype vaccine freshly extracted from the vPRV/XJ-5 at the same dose were administered to evaluate the immune effectiveness thereof on growing pigs to prevent lethal strikes caused by vPRV/XJ-5. The results suggest that the Bartha-K61 vaccine at a dose of 1 × 106.0 TCID50 per animal and the same dosage of the rPRV/XJ5-gI−/gE−/TK− prototype vaccine protected growing pigs against the lethal challenge of vPRV/XJ-5 strain with 100% survive rate. Furthermore, the outcome of the clinical score, virus shedding, weight gain, and viral loads in different pig tissues in these two groups demonstrates that either the Bartha-K61 vaccine or the rPRV/XJ5-gI−/gE−/TK− prototype vaccine at the same dose exhibited parallel efficacy in pigs against the lethal challenge with the XJ-5 strain of vPRV.
Keywords
- pseudorabies
- variant pseudorabies virus
- Bartha-K61 vaccine
- rPRV/XJ5-gI−/gE−/TK− prototype vaccine
- efficacy
- growing pigs
