Nanosecond electric pulses are equally effective in electrochemotherapy with cisplatin as microsecond pulses

Abstract

Nanosecond electric pulses showed promising results in electrochemotherapy, but the underlying mechanisms of action are still unexplored. The aim of this work was to correlate cellular cisplatin amount with cell survival of cells electroporated with nanosecond or standardly used 8 × 100 μs pulses and to investigate the effects of electric pulses on cisplatin structure.

Keywords

• electroporation
• electrochemotherapy
• nanosecond pulses
• cisplatin