The Effect Of Melatonin On The Leptin And Growth Hormone In Mice

Abstract

Melatonin is a hormone secreted by the pineal gland in response to darkness, because of that it named hormone of darkness. Melatonin has generated an important deal of interest as a therapeutic modality for many diseases especially sleep disorders. Melatonin and leptin show a role in energy metabolism and circadian variation. A relationship between these hormones has been discussed. Melatonin has been appearing to be able to positively affecting the leptin in the circulation. Also, Growth hormone (GH) and melatonin belong to the group of growth factors. This research assume to measure the effect that happened on leptin and growth hormone under the melatonin treatment by using male and female albino, laboratory-bred mice, 72 mice were divided to 3 groups, group A as control group, group B with 3mg and group C that treated with 12mg melatonin . The killing process was done in 2 stages (6 and 10 weeks). Blood samples were taken and analyzed In addition. The results were proved significantly higher levels of plasma leptin and GH in mice that treated with melatonin compared to control mice. Our discovery from this study that melatonin elevate the leptin and GH levels in blood, decrease the body weight.

Keywords

• growth hormone
• leptin
• melatonin
• body wight