Nature Communications (Oct 2022)
Proteo-genomic characterization of virus-associated liver cancers reveals potential subtypes and therapeutic targets
- Masashi Fujita,
- Mei-Ju May Chen,
- Doris Rieko Siwak,
- Shota Sasagawa,
- Ayako Oosawa-Tatsuguchi,
- Koji Arihiro,
- Atsushi Ono,
- Ryoichi Miura,
- Kazuhiro Maejima,
- Hiroshi Aikata,
- Masaki Ueno,
- Shinya Hayami,
- Hiroki Yamaue,
- Kazuaki Chayama,
- Ju-Seog Lee,
- Yiling Lu,
- Gordon B. Mills,
- Han Liang,
- Satoshi S. Nishizuka,
- Hidewaki Nakagawa
Affiliations
- Masashi Fujita
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Mei-Ju May Chen
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Doris Rieko Siwak
- Department of Systems Biology to Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Shota Sasagawa
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Ayako Oosawa-Tatsuguchi
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Koji Arihiro
- Department of Anatomical Pathology, Hiroshima University Hospital
- Atsushi Ono
- Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University
- Ryoichi Miura
- Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University
- Kazuhiro Maejima
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- Hiroshi Aikata
- Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University
- Masaki Ueno
- Second Department of Surgery, Wakayama Medical University
- Shinya Hayami
- Second Department of Surgery, Wakayama Medical University
- Hiroki Yamaue
- Second Department of Surgery, Wakayama Medical University
- Kazuaki Chayama
- Department of Gastroenterology and Metabolism, Graduate School of Biomedical and Health Sciences, Hiroshima University
- Ju-Seog Lee
- Department of Systems Biology to Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Yiling Lu
- Department of Systems Biology to Genomic Medicine, The University of Texas MD Anderson Cancer Center
- Gordon B. Mills
- Division of Oncological Sciences, Knight Cancer Institute, Oregon Health & Science University
- Han Liang
- Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
- Satoshi S. Nishizuka
- Division of Biomedical Research and Development, Institute of Biomedical Sciences, Iwate Medical University
- Hidewaki Nakagawa
- Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences
- DOI
- https://doi.org/10.1038/s41467-022-34249-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
The molecular heterogeneity of primary liver cancer remains to be characterised. Here, the authors perform multi-omics analysis of 259 primary liver cancer tissues and identify three distinct molecular subtypes.
