Psychiatric Diagnoses and Medications in Wolfram Syndrome

Abstract

Wolfram Syndrome is a rare genetic disorder usually resulting from pathogenic variation in the WFS1 gene, which leads to an exaggerated endoplasmic reticulum (ER) stress response. The disorder is typically characterized by diabetes insipidus, diabetes mellitus, optic nerve atrophy, hearing loss, and neurodegenerative features. Existing literature suggests it may also have psychiatric manifestations.

Keywords

• wolfram syndrome
• psychiatry
• anxiety
• obsessive compulsive disorder
• medication
• er stress