Zhongguo quanke yixue (Sep 2023)
Correlation between the Severity of Metabolic-associated Fatty Liver Disease and Thyroid Nodules
Abstract
Background Both fatty liver disease and thyroid nodules are common clinical chronic diseases that are closely related to metabolism, but there is little research on whether there is a certain correlation between them. Objective To explore the overall and disease severity-specific correlations between metabolic-associated fatty liver disease (MAFLD) and thyroid nodules. Methods This study selected 666 MAFLD patients〔including 316 mild cases (group A) , and 350 moderate to severe cases (group B) 〕, and 330 health examinees (group C) from Shengjing Hospital of China Medical University from December 2020 to December 2021. All the subjects underwent general anthropometric measurement, blood tests and ultrasound examination of the liver and thyroid. Multivariate Logistic regression was used to explore the influencing factors of thyroid nodules in MAFLD. Results The prevalence rate of thyroid nodules in group C (19.70%, 65/330) was lower than that in group A (25.36%, 81/316) or B (34.86%, 122/350) (P<0.05) . Compared with group A, group B had higher prevalence rate of thyroid nodules (P<0.05) , and higher prevalence rates of C-TIRADS 3 and ≥4 thyroid nodules (P<0.05) . Multivariate Logistic regression analysis showed that age (OR=1.447) , BMI (OR=2.847) , triacylglycerol (TG) (OR=2.947) , total cholesterol (TC) (OR=3.235) , fasting plasma glucose (FPG) (OR=2.780) and glycated haemoglobin (HbA1c) (OR=3.371) were the risk factors of thyroid nodules in MAFLD (P<0.05) . Conclusion MAFLD is associated with increased prevalence rate of thyroid nodules. The risk of malignant thyroid nodules increases with the aggravation of hepatic steatosis (namely progression from mild/moderate to severe) . Age, BMI, TG, TC, FPG and HbA1c are associated factors of MAFLD complicated with thyroid nodules.
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