Nature Communications (Jan 2023)

Structural mechanism of BRD4-NUT and p300 bipartite interaction in propagating aberrant gene transcription in chromatin in NUT carcinoma

  • Di Yu,
  • Yingying Liang,
  • Claudia Kim,
  • Anbalagan Jaganathan,
  • Donglei Ji,
  • Xinye Han,
  • Xuelan Yang,
  • Yanjie Jia,
  • Ruirui Gu,
  • Chunyu Wang,
  • Qiang Zhang,
  • Ka Lung Cheung,
  • Ming-Ming Zhou,
  • Lei Zeng

DOI
https://doi.org/10.1038/s41467-023-36063-5
Journal volume & issue
Vol. 14, no. 1
pp. 1 – 16

Abstract

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BRD4-NUT’s bipartite binding and activation of p300 in NUT carcinoma nucleates a feed-forward spread of histone hyperacetylation and chromatin condensation that sustains aberrant pro-proliferation gene transcription and perpetual tumor cell growth.