African Journal of Nephrology (Sep 2009)

Adrenomedullin in patients with type 2 diabetes and kidney disease

  • Emam Waked,
  • Omnia El Bendary,
  • Amna Metwaly,
  • Khaled Younes,
  • Heba Sayed Assal,
  • Hanan Ali Sayed

DOI
https://doi.org/10.21804/13-1-775
Journal volume & issue
Vol. 13, no. 1
pp. 19 – 25

Abstract

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Secreting vasoactive factors such asadrenomedullin (AM) has been intensively investigated due to its vascular protective properties and promising potential as a therapeutic target. The relationship between adrenomedullin and type (2)diabetes needs to be elucidated as it is associated with significant elevation in plasma adrenomedullin levels. The aim of this study was to evaluate the role of adrenomedullin in the development of vasculopathy and its significance as a marker denoting renal affection in type 2 diabetic patients. Materials and Methods: This study was conducted on 60 diabetic patients, 20 without nephropathy, 20with nephropathy & 20 with diabetic nephropathy(DN) on haemodialysis as well as 20 age- and sex matched healthy controls. All were subjected to full history, Echocardiography, lipid profile analysis and plasma adrenomedullin using ELISA method. Results: plasma AM concentration was elevated in all groups of diabetic patients and increment was dependent on the severity of DN (P<0.0001,P<0.0001, P<0.0001 respectively). There were positive correlation between adrenomedullin and left ventricular internal dimensions both in diastole& systole (P<0.001, P<0.005) and negative correlation between AM and ejection fraction (EF)P<0.0001. There was positive correlation between adrenomedullin and cholesterol, triglycerides and LDL (p<0.002, p<0.001and p<0.003 respectively)and a negative correlation with HDL (P<0.004).Conclusion: Adrenomedullin is supposed to play a role in the pathogenesis of diabetic microvasculopathy in renal patients. So it can be used to identify high-risk subjects and modulating its action would have therapeutic potential in the prevention of diabetic nephropathy.

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