Nature Communications (Mar 2017)

A genome-wide screen identifies YAP/WBP2 interplay conferring growth advantage on human epidermal stem cells

  • Gernot Walko,
  • Samuel Woodhouse,
  • Angela Oliveira Pisco,
  • Emanuel Rognoni,
  • Kifayathullah Liakath-Ali,
  • Beate M. Lichtenberger,
  • Ajay Mishra,
  • Stephanie B. Telerman,
  • Priyalakshmi Viswanathan,
  • Meike Logtenberg,
  • Lisa M. Renz,
  • Giacomo Donati,
  • Sven R. Quist,
  • Fiona M. Watt

DOI
https://doi.org/10.1038/ncomms14744
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 16

Abstract

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Individual human epidermal cells differ in their self-renewal ability. Here the authors perform genome-wide pooled RNAi screens to uncover the molecular basis for this heterogeneity, and identify genes conferring a clonal growth advantage on normal and neoplastic human epidermal cells.