Prognostic factors of hyperbaric oxygen therapy for patients with delayed encephalopathy after acute carbon monoxide poisoning
Fangling Huang,
Lin Yang,
Zhen Tan,
Bangmin Yang,
Pingqiong Liu,
Zuomin Li,
Wanli Shi,
Kun Peng,
Jing Yuan,
Qing He,
Li Yang,
Xinyu Li,
Can Li,
Dezhong Chen,
Zhengrong Peng
Affiliations
Fangling Huang
Department of Hyperbaric Oxygen, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China
Lin Yang
Department of Hyperbaric Oxygen, Changsha Central Hospital, Changsha, Hunan Province 410028, China
Zhen Tan
Department of Hyperbaric Oxygen, The First People’s Hospital of Changde City, Changde, Hunan Province 415003, China
Bangmin Yang
Department of Hyperbaric Oxygen, The First People’ Hospital of Huaihua, Huaihua, Hunan Province 418099, China
Pingqiong Liu
Department of Hyperbaric Oxygen, Yiyang Central Hospital, Yiyang, Hunan Province 413099, China
Zuomin Li
Department of Hyperbaric Oxygen, Chenzhou No 1 People’s Hospital, Chenzhou, Hunan Province 423099, China
Wanli Shi
Department of Hyperbaric Oxygen, People’ Hospital of Xiangxi Tujia and Miao Autonomous Prefecture, Jishou, Hunan Province 416007, China
Kun Peng
Department of Hyperbaric Oxygen, Yueyang Central Hospital, Yueyang, Hunan Province 414020, China
Jing Yuan
Department of Hyperbaric Oxygen, Zhangjiajie People’s Hospital, Zhangjiajie, Hunan Province 427099, China
Qing He
Department of Neurosurgery, Yongzhou Central Hospital, Yongzhou, Hunan Province 425002, China
Li Yang
Department of Hyperbaric Oxygen, Central Hospital of Shaoyang, Shaoyang, Hunan Province 422099, China
Xinyu Li
Department of Hyperbaric Oxygen, Hengyang Central Hospital, Hengyang, Hunan Province 421001, China
Can Li
Department of Hyperbaric Oxygen, Xiangya Boai Rehabilitation Hospital, Changsha, Hunan Province 410199, China
Dezhong Chen
Department of Hyperbaric Oxygen, Zhuzhou Central Hospital, Zhuzhou, Hunan Province 412001, China
Zhengrong Peng
Department of Hyperbaric Oxygen, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan Province 410008, China; Corresponding author.
Delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) is a disease with an incomplete pathological mechanism, long treatment time, and uncertain factors affecting the therapeutic effect. This study explored prognostic factors for DEACMP patients treated with hyperbaric oxygen therapy (HBOT) in 15 hospitals in China. The findings might provide a theoretical basis for further improving the prognosis of DEACMP patients.In this study, data from 330 patients with DEACMP who were admitted to HBOT centers of 15 hospitals in Hunan Province (China) from June 2015 to June 2020 were retrospectively analyzed, and their medical records related to disease prognosis were collected and followed up by telephone. Univariate and multivariate analyses were used to identify independent risk factors for the prognosis of DEACMP patients after HBOT. Univariate analysis revealed 11 possible prognostic factors. Consistent with univariate analysis, multivariate analysis found that underlying diseases (Odds radio(OR) = 2.886, P = 0.048), hypermyotonia (OR = 5.2558, P = 0.008), and HBOT pressure no less Than 2.3 atm absolute (ATA) ((OR = 7.812, P = 0.004) were identified as independent prognostic factors among 20 variables for poor prognosis of DEACMP patients treated with HBOT in the study. This multicenter retrospective analysis revealed that the adverse prognostic markers for DEACMP patients treated with HBOT might be underlying diseases, hypermyotonia, and an HBOT pressure of 2.3 ATA or higher.
