Bolus streptokinase administration in acute myocardial infarction: features of hypotensive reaction

Abstract

Hypotension prevalence and severity was investigated in two regimens of streptokinase (SK) administration in acute myocardial infarction (AMI). Group I (n = 17) received intravenous SK, 0.75 mln IE, in 10 minutes; Group II (n = 9) - 1.5 mln IE, in 45 minutes. In bolus SK administration, maximal blood pressure (BP) decrease was comparable to that in slow infusion group, but observed earlier - at minute 7.5 ± 0,4, vs minute 12.5 ± 6.8 (p = 0.003). In Group I, 3 cases of collapse were registered, with little effect from mezaton administration. Significant BPfall could be expected in patients with posterior MI, right wall damage and bradycardia. To prevent severe hypotensive reaction, bolus SK administration should be optimized.

Keywords

• myocardial infarction
• streptokinase
• hypotension
• no