Plasma 25-Hydroxyvitamin D and 1,25-Dihydroxyvitamin D Levels in Breast Cancer Risk in Mali: A Case–Control Study
Aboubacar D. T. Bissan,
Madani Ly,
Awo Emmanuela H. Amegonou,
Fatoumata M. Sidibe,
Bocary S. Koné,
Nènè Oumou K. Barry,
Madiné Tall,
Lassana G. Timbiné,
Bourèma Kouriba,
Pascal Reynier,
Zahra Ouzzif
Affiliations
Aboubacar D. T. Bissan
Biochemistry, Metabolic and Molecular Unit, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat 10100, Morocco
Madani Ly
University Hospital of Luxembourg, Bamako BPE91094, Mali
Awo Emmanuela H. Amegonou
Biology Teaching and Research Department, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako BPE423, Mali
Fatoumata M. Sidibe
Biology Teaching and Research Department, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako BPE423, Mali
Bocary S. Koné
Biology Teaching and Research Department, Faculty of Pharmacy, University of Sciences, Techniques and Technologies of Bamako (USTTB), Bamako BPE423, Mali
Nènè Oumou K. Barry
Pharmaceutical Biochemistry Laboratory, Cheikh Anta Diop University of Dakar, Dakar BP 5005, Senegal
Madiné Tall
Charles-Merieux Center for Infectiology (CMIC) of Bamako, Bamako BPE2283, Mali
Lassana G. Timbiné
Charles-Merieux Center for Infectiology (CMIC) of Bamako, Bamako BPE2283, Mali
Bourèma Kouriba
Charles-Merieux Center for Infectiology (CMIC) of Bamako, Bamako BPE2283, Mali
Pascal Reynier
Department of Biochemistry and Molecular Biology, University Hospital of Angers, 49933 Angers, France
Zahra Ouzzif
Biochemistry, Metabolic and Molecular Unit, Faculty of Medicine and Pharmacy of Rabat, Mohammed V University of Rabat, Rabat 10100, Morocco
(1) Background: Breast cancer is the most prevalent cancer found in women in Mali. The aim of the current study was to determine the association between metabolites circulating in the blood, 25(OH)D and 1,25(OH)2D, and vitamin D levels with the risk of breast cancer in Malian women. (2) Methods: We conducted a prospective case–control study from August 2021 to March 2022. Control subjects were matched to cases according to age (within 5 years). The patients’ clinical stage was determined by the oncologist according to the tumour–nodes–metastasis (TNM) classification system. (3) Results: We observed no differences in the mean 25(OH)D (p = 0.221) and 1,25(OH)2D (p = 0.285) between cases and controls. However, our findings indicate a more pronounced inverse association in the first level of plasma 25(OH)D, while the risk function decreases at higher levels. This observation takes strength with 1,25(OH)2D by a significant association between the first quartile and breast cancer as a risk factor (p = 0.03; OR = 71.84; CI: 1.36–3785.34). (4) Conclusions: These outcomes showed a possible association between 25(OH)D and 1,25(OH)2D in decreasing the risk of breast cancer.
