Association Between Succinate Receptor SUCNR1 Expression and Immune Infiltrates in Ovarian Cancer

Jiawen Zhang; Qinyi Zhang; Yongbin Yang; Qingying Wang

doi:10.3389/fmolb.2020.00150

Frontiers in Molecular Biosciences (Aug 2020)

Association Between Succinate Receptor SUCNR1 Expression and Immune Infiltrates in Ovarian Cancer

Jiawen Zhang,
Qinyi Zhang,
Yongbin Yang,
Qingying Wang

Affiliations

Jiawen Zhang: Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China
Qinyi Zhang: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China
Yongbin Yang: Department of Obstetrics and Gynecology, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, China
Qingying Wang: Department of Obstetrics and Gynecology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, China

DOI: https://doi.org/10.3389/fmolb.2020.00150
Journal volume & issue: Vol. 7

Abstract

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BackgroundThe activation of succinate receptor 1 (SUCNR1) by extracellular succinate has been found to regulate immune cell function. However, the clinical significance of SUCNR1 in ovarian cancer and its correlation with tumor-infiltrating lymphocytes remain unclear.MethodsThe genetic alteration and expression patterns of SUCNR1 were analyzed by using cBioPortal and Gene Expression Omnibus (GEO) datasets. Kaplan-Meier Plotter was used to assess the prognostic value of SUCNR1 in patients with ovarian cancer. The correlations between SUCNR1 expression and immune infiltration, gene markers of immune cells, cytokines, chemokines, or T cell exhaustion were explored by using TIMER and TISIDB platforms. We also performed Gene Set Enrichment Analysis (GSEA) to reveal biological function of SUCNR1 in ovarian cancer.ResultsThe expression of SUCNR1 was closely related to tumor infiltrating lymphocytes, multiple gene markers of immune cells, and T cell exhaustion in ovarian cancer. The expression of SUCNR1 was also associated with the expression of cytokine- or chemokine-related genes. Moreover, GSEA revealed that various immune-related pathways might be regulated by SUCNR1. In addition, we found that SUCNR1 was amplified in ovarian cancer, and the high expression of SUCNR1 predicted worse progression-free survival (p = 0.0073, HR = 1.49, 95% CI = 1.11–2).ConclusionThese results highlight the role of SUCNR1 in regulating tumor immunity in ovarian cancer.

Published in Frontiers in Molecular Biosciences

ISSN: 2296-889X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/molecular-biosciences

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