Impact of Amitryptiline on Migraine Disability Assessment Score

Abstract

Aim: Migraine headache is a common disorder, several drugs have been tried as a prophylaxis to reduce the attacks of headache. Aim of this study is to see the impact of amitriptyline on quality of life in migraneurs using Migraine Disability Assessment Score. Materials and Methods: In this study 300 patients of either gender who required prophylaxis for migraine without aura were selected. The patients were of the age group 18-60 years. The MIDAS questionnaire was administered to patients before starting treatment and again after 45 days prophylaxis. The improvement was noted. Statistical Analysis: It is a prospective study where the severity of symptoms and ‘quality of life’ in patients is assessed before and after treatment using mean, frequency, standard deviation and paired‘t’ test. Results: A total of 300 patients were subjected to migraine prophylaxis with amiptriptyline. The study showed female preponderance. The mean MIDAS score before and after treatment with amitriptyline was 11.6 and 9.4 respectively. The student‘t’ test showed p-value of <0.005 which was significant. Conclusion: Migraine prophylaxis with amitriptyline for a period of 45 days decreased the severity of symptoms and also reduction in days of migraine attacks. However the long term effects on quality of life could not be assessed. The study needs to be conducted in a large scale to evaluate the consistency and accuracy of the test.

Keywords

• amytriptyline
• midas