Frontiers in Pharmacology (Oct 2022)
Integrating network pharmacology and experimental verification to decipher the immunomodulatory effect of Bu-Zhong-Yi-Qi-Tang against poly (I:C)-induced pulmonary inflammation
- Liufang Hu,
- Liufang Hu,
- Marina Yamamoto,
- Jiali Chen,
- Huifang Duan,
- Jing Du,
- Liangliang He,
- Danfeng Shi,
- Xinsheng Yao,
- Xinsheng Yao,
- Takayuki Nagai,
- Takayuki Nagai,
- Hiroaki Kiyohara,
- Hiroaki Kiyohara,
- Zhihong Yao,
- Zhihong Yao
Affiliations
- Liufang Hu
- College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
- Liufang Hu
- Laboratory of Biochemical Pharmacology for Phytomedicines, Ōmura Satoshi Memorial Institute and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
- Marina Yamamoto
- Laboratory of Biochemical Pharmacology for Phytomedicines, Ōmura Satoshi Memorial Institute and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
- Jiali Chen
- College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
- Huifang Duan
- College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
- Jing Du
- Tong Ren Tang Technologies Co. Ltd, Beijing, China
- Liangliang He
- College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
- Danfeng Shi
- College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
- Xinsheng Yao
- College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
- Xinsheng Yao
- International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, China
- Takayuki Nagai
- Laboratory of Biochemical Pharmacology for Phytomedicines, Ōmura Satoshi Memorial Institute and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
- Takayuki Nagai
- Oriental Medicine Research Center, Kitasato University, Tokyo, Japan
- Hiroaki Kiyohara
- Laboratory of Biochemical Pharmacology for Phytomedicines, Ōmura Satoshi Memorial Institute and Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan
- Hiroaki Kiyohara
- Oriental Medicine Research Center, Kitasato University, Tokyo, Japan
- Zhihong Yao
- College of Pharmacy, Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China
- Zhihong Yao
- International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China, Jinan University, Guangzhou, China
- DOI
- https://doi.org/10.3389/fphar.2022.1015486
- Journal volume & issue
-
Vol. 13
Abstract
Graphical Abstract
Keywords
- Bu-zhong-yi-qi-tang
- traditional Chinese medicine formula
- pulmonary inflammation
- immunomodulatory effect
- network pharmacology
- leukocyte transendothelial migration