Critical role for arginase 2 in obesity-associated pancreatic cancer

Tamara Zaytouni; Pei-Yun Tsai; Daniel S. Hitchcock; Cory D. DuBois; Elizaveta Freinkman; Lin Lin; Vicente Morales-Oyarvide; Patrick J. Lenehan; Brian M. Wolpin; Mari Mino-Kenudson; Eduardo M. Torres; Nicholas Stylopoulos; Clary B. Clish; Nada Y. Kalaany

doi:10.1038/s41467-017-00331-y

Nature Communications (Aug 2017)

Critical role for arginase 2 in obesity-associated pancreatic cancer

Tamara Zaytouni,
Pei-Yun Tsai,
Daniel S. Hitchcock,
Cory D. DuBois,
Elizaveta Freinkman,
Lin Lin,
Vicente Morales-Oyarvide,
Patrick J. Lenehan,
Brian M. Wolpin,
Mari Mino-Kenudson,
Eduardo M. Torres,
Nicholas Stylopoulos,
Clary B. Clish,
Nada Y. Kalaany

Affiliations

Tamara Zaytouni: Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s Hospital
Pei-Yun Tsai: Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s Hospital
Daniel S. Hitchcock: Broad Institute of Harvard and MIT
Cory D. DuBois: Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s Hospital
Elizaveta Freinkman: Whitehead Institute for Biomedical Research
Lin Lin: Department of Pediatrics, Harvard Medical School
Vicente Morales-Oyarvide: Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School
Patrick J. Lenehan: Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s Hospital
Brian M. Wolpin: Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School
Mari Mino-Kenudson: Department of Pathology, Massachusetts General Hospital and Harvard Medical School
Eduardo M. Torres: Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School
Nicholas Stylopoulos: Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s Hospital
Clary B. Clish: Broad Institute of Harvard and MIT
Nada Y. Kalaany: Division of Endocrinology, Center for Basic and Translational Obesity Research, Boston Children’s Hospital

DOI: https://doi.org/10.1038/s41467-017-00331-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Obesity is an established risk factor for pancreatic ductal adenocarcinoma (PDA). Here the authors show that obesity induces the expression of the mitochondrial form of arginase ARG2 in PDA and that ARG2 silencing or loss results in ammonia accumulation and suppression of obesity-driven PDA tumor growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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