C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer

Xiao-Zheng Liu; Anastasiia Rulina; Man Hung Choi; Line Pedersen; Johanna Lepland; Sina T. Takle; Noelly Madeleine; Stacey D’mello Peters; Cara Ellen Wogsland; Sturla Magnus Grøndal; James B. Lorens; Hani Goodarzi; Per E. Lønning; Stian Knappskog; Anders Molven; Nils Halberg

doi:10.1038/s41467-021-27734-2

Nature Communications (Jan 2022)

C/EBPB-dependent adaptation to palmitic acid promotes tumor formation in hormone receptor negative breast cancer

Xiao-Zheng Liu,
Anastasiia Rulina,
Man Hung Choi,
Line Pedersen,
Johanna Lepland,
Sina T. Takle,
Noelly Madeleine,
Stacey D’mello Peters,
Cara Ellen Wogsland,
Sturla Magnus Grøndal,
James B. Lorens,
Hani Goodarzi,
Per E. Lønning,
Stian Knappskog,
Anders Molven,
Nils Halberg

Affiliations

Xiao-Zheng Liu: Department of Biomedicine, University of Bergen
Anastasiia Rulina: Department of Biomedicine, University of Bergen
Man Hung Choi: Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen
Line Pedersen: Department of Biomedicine, University of Bergen
Johanna Lepland: Department of Biomedicine, University of Bergen
Sina T. Takle: Department of Biomedicine, University of Bergen
Noelly Madeleine: Department of Biomedicine, University of Bergen
Stacey D’mello Peters: Department of Biomedicine, University of Bergen
Cara Ellen Wogsland: Department of Biomedicine, University of Bergen
Sturla Magnus Grøndal: Department of Biomedicine, University of Bergen
James B. Lorens: Department of Biomedicine, University of Bergen
Hani Goodarzi: Department of Biophysics and Biochemistry, University of California San Francisco
Per E. Lønning: Department of Clinical Science, Faculty of Medicine, University of Bergen
Stian Knappskog: Department of Clinical Science, Faculty of Medicine, University of Bergen
Anders Molven: Gade Laboratory for Pathology, Department of Clinical Medicine, University of Bergen
Nils Halberg: Department of Biomedicine, University of Bergen

DOI: https://doi.org/10.1038/s41467-021-27734-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 17

Abstract

Read online

Obesity is linked to cancer risk in post-menopausal breast cancer. At the molecular level this is governed by cellular adaption to palmitic acid through epigenetic activation of a C/EBPB-dependent transcriptional network that drives tumor formation.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal