Host Defense Peptides from Asian Frogs as Potential Clinical Therapies
Vineeth T.V. Kumar,
David Holthausen,
Joshy Jacob,
Sanil George
Affiliations
Vineeth T.V. Kumar
Molecular Ecology Lab, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala 695014, India
David Holthausen
Emory Vaccine Center, Department of Microbiology and Immunology, Emory University, Yerkes National Primate Research Center, 954 Gatewood Rd, Atlanta, GA 30329, USA
Joshy Jacob
Emory Vaccine Center, Department of Microbiology and Immunology, Emory University, Yerkes National Primate Research Center, 954 Gatewood Rd, Atlanta, GA 30329, USA
Sanil George
Molecular Ecology Lab, Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala 695014, India
Host defense peptides (HDPs) are currently major focal points of medical research as infectious microbes are gaining resistance to existing drugs. They are effective against multi-drug resistant pathogens due to their unique primary target, biological membranes, and their peculiar mode of action. Even though HDPs from 60 Asian frog species belonging to 15 genera have been characterized, research into these peptides is at a very early stage. The purpose of this review is to showcase the status of peptide research in Asia. Here we provide a summary of HDPs from Asian frogs.
