Nature Communications (Sep 2016)

Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency

  • Alessandro Fiorenzano,
  • Emilia Pascale,
  • Cristina D'Aniello,
  • Dario Acampora,
  • Cecilia Bassalert,
  • Francesco Russo,
  • Gennaro Andolfi,
  • Mauro Biffoni,
  • Federica Francescangeli,
  • Ann Zeuner,
  • Claudia Angelini,
  • Claire Chazaud,
  • Eduardo J. Patriarca,
  • Annalisa Fico,
  • Gabriella Minchiotti

DOI
https://doi.org/10.1038/ncomms12589
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 16

Abstract

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Stem cell plasticity is crucial for early embryo development and the differentiation of stem cells. Here, the authors show that the extracellular protein Cripto sustains mouse ESC self-renewal and maintains mouse EpiSC as well as human ESC pluripotency and controls the metabolic reprogramming in ESCs to EpiSC transition.