Brain Organization and Human Diseases

Abstract

The cortex is a highly organized structure that develops from the caudal regions of the segmented neural tube. Its spatial organization sets the stage for future functional arealization. Here, we suggest using a developmental perspective to describe and understand the etiology of common cortical malformations and their manifestation in the human brain.

Keywords

• cortical development
• neuronal migration
• holoprosencephaly
• lissencephaly
• forebrain
• telencephalon