Nature Communications (May 2021)
Immune cellular networks underlying recovery from influenza virus infection in acute hospitalized patients
- Thi H. O. Nguyen,
- Marios Koutsakos,
- Carolien E. van de Sandt,
- Jeremy Chase Crawford,
- Liyen Loh,
- Sneha Sant,
- Ludivine Grzelak,
- Emma K. Allen,
- Tim Brahm,
- E. Bridie Clemens,
- Maria Auladell,
- Luca Hensen,
- Zhongfang Wang,
- Simone Nüssing,
- Xiaoxiao Jia,
- Patrick Günther,
- Adam K. Wheatley,
- Stephen J. Kent,
- Malet Aban,
- Yi-Mo Deng,
- Karen L. Laurie,
- Aeron C. Hurt,
- Stephanie Gras,
- Jamie Rossjohn,
- Jane Crowe,
- Jianqing Xu,
- David Jackson,
- Lorena E. Brown,
- Nicole La Gruta,
- Weisan Chen,
- Peter C. Doherty,
- Stephen J. Turner,
- Tom C. Kotsimbos,
- Paul G. Thomas,
- Allen C. Cheng,
- Katherine Kedzierska
Affiliations
- Thi H. O. Nguyen
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Marios Koutsakos
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Carolien E. van de Sandt
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Jeremy Chase Crawford
- Department of Immunology, St Jude Children’s Research Hospital
- Liyen Loh
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Sneha Sant
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Ludivine Grzelak
- Biology Department, École Normale Supérieure Paris-Saclay, Université Paris-Saclay Cachan
- Emma K. Allen
- Department of Immunology, St Jude Children’s Research Hospital
- Tim Brahm
- Department of Immunology, St Jude Children’s Research Hospital
- E. Bridie Clemens
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Maria Auladell
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Luca Hensen
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Zhongfang Wang
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Simone Nüssing
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Xiaoxiao Jia
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Patrick Günther
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Adam K. Wheatley
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Stephen J. Kent
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Malet Aban
- World Health Organisation (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity
- Yi-Mo Deng
- World Health Organisation (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity
- Karen L. Laurie
- World Health Organisation (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity
- Aeron C. Hurt
- World Health Organisation (WHO) Collaborating Centre for Reference and Research on Influenza, at The Peter Doherty Institute for Infection and Immunity
- Stephanie Gras
- Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Jamie Rossjohn
- Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Jane Crowe
- Deepdene Surgery
- Jianqing Xu
- Shanghai Public Health Clinical Centre and Institutes of Biomedical Sciences, Key Laboratory of Medical Molecular Virology of Ministry of Education/Health, Shanghai Medical College, Fudan University
- David Jackson
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Lorena E. Brown
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Nicole La Gruta
- Infection and Immunity Program & Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University
- Weisan Chen
- Department of Biochemistry and Genetics, La Trobe Institute For Molecular Science, La Trobe University
- Peter C. Doherty
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- Stephen J. Turner
- Department of Microbiology, Biomedicine Discovery Institute, Monash University
- Tom C. Kotsimbos
- Department of Allergy, Immunology and Respiratory Medicine, The Alfred Hospital
- Paul G. Thomas
- Department of Immunology, St Jude Children’s Research Hospital
- Allen C. Cheng
- School of Public Health and Preventive Medicine, Monash University
- Katherine Kedzierska
- Department of Microbiology and Immunology, University of Melbourne, at the Peter Doherty Institute for Infection and Immunity
- DOI
- https://doi.org/10.1038/s41467-021-23018-x
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
The immunological parameters that define severe influenza disease are not clear within human real time infections. Here the authors compare a severe influenza infection cohort with an influenza vaccinated cohort to understand correlates of severe influenza disease.
