Investigating the Clinico-Pathological Parameters in Astrocytoma

Abstract

Background and Objective: Astrocytoma is a tumor of neurological origin, arising from special supportive cells in the brain and spinal cord called the astrocytes. Astrocytoma is classified according to grade, site, and molecular features. The aim of this study is to investigate the relationship between histopathological and clinical parameters and gender, age, location and different grades. Methods: This cross-sectional study included 36 cases of astrocytoma from April 2017 to June 2020 from the archive of AL Shaheed Gazi AL Hariri Hospital. The cases reached the final diagnosis by H&E staining with 16 cases stained by immunohistochemical stain for confirmation of diagnosis. SPSS was used for analysis. Findings: Thirty-six cases of astrocytoma were included in this study. Their ages were ranging from 1 to 56 years, with a mean age of 31.43±0.015 years. Assessment of age reveals that the most frequent age (25%) was in the 3rd decade of life. The predominant grades were grade I and grade IV with 11 cases for each (32.5%). Whereas patients of grade II and III compose 10 (27%), and 4 (11%) cases, respectively. The relationship between the age of the patients and their grades shows a positive significant correlation between age and grade (p<0.001), and tumor grade increases with the increase in the age of the patients. Conclusion: The results of the study show that there is a significant relationship between tumor grade and clinical-pathological characteristics, because tumor grade increases with age and is more aggressive in female patients.

Keywords

• astrocytoma
• histopathological
• grading
• who classification.