Innovations in acute stroke reperfusion strategies

Abstract

Vascular neurology is witnessing unprecedented innovations in the management of acute ischemic stroke, especially in reperfusion strategies. The emergence of mechanical thrombectomy with new generation devices has revolutionized the treatment of acute ischemic stroke with large vessel occlusion. The reperfusion strategies are evolving with the extension of the window period for thrombolysis and endovascular therapy through the concept of “tissue clock” in addition to the established “time clock.” The newer generation of thrombolytic drugs like tenecteplase are promising exciting times ahead in acute stroke care. In this “viewpoint,'” the evolution of reperfusion therapy in acute ischemic stroke will be discussed followed by recent innovations in reperfusion strategies.

Keywords

• Acute stroke therapy
• ischemic stroke
• magnetic resonance imaging
• recombinant tissue plasminogen activator
• reperfusion therapy
• tenecteplase
• thrombectomy
• thrombolytic therapy