A case of perivascular epithelioid nodules arising in an intramural leiomyoma

Yoldez Houcine; Karima Mekni; Emna Brahem; Mouna Mlika; Aida Ayadi; Chiraz Fekih; Imene Ridene; Faouzi El Mezni

Human Pathology: Case Reports (Mar 2021)

A case of perivascular epithelioid nodules arising in an intramural leiomyoma

Yoldez Houcine,
Karima Mekni,
Emna Brahem,
Mouna Mlika,
Aida Ayadi,
Chiraz Fekih,
Imene Ridene,
Faouzi El Mezni

Affiliations

Yoldez Houcine: Pathology Department, Abd Errahmen Mami Hospital, Ariana, Tunisia; Faculty of Medicine, El Manar University, Tunis, Tunisia; Research Laboratory, LR18SP06, Tunis, Tunisia; Corresponding author at: Pathology Department, Abderrahmen Mami Hospital, 2080 Ariana, Tunisia.
Karima Mekni: Gynecological and Obstetric Department, Mahmoud El Matri Hospital, Ariana, Tunisia; Faculty of Medicine, El Manar University, Tunis, Tunisia
Emna Brahem: Pathology Department, Abd Errahmen Mami Hospital, Ariana, Tunisia; Faculty of Medicine, El Manar University, Tunis, Tunisia; Research Laboratory, LR18SP06, Tunis, Tunisia
Mouna Mlika: Pathology Department, Abd Errahmen Mami Hospital, Ariana, Tunisia; Faculty of Medicine, El Manar University, Tunis, Tunisia; Research Laboratory, LR18SP06, Tunis, Tunisia
Aida Ayadi: Pathology Department, Abd Errahmen Mami Hospital, Ariana, Tunisia; Faculty of Medicine, El Manar University, Tunis, Tunisia; Research Laboratory, LR18SP06, Tunis, Tunisia
Chiraz Fekih: Gynecological and Obstetric Department, Mahmoud El Matri Hospital, Ariana, Tunisia; Faculty of Medicine, El Manar University, Tunis, Tunisia
Imene Ridene: Radiology Department, Mahmoud El Matri Hospital, Ariana, Tunisia; Faculty of Medicine, El Manar University, Tunis, Tunisia
Faouzi El Mezni: Pathology Department, Abd Errahmen Mami Hospital, Ariana, Tunisia; Faculty of Medicine, El Manar University, Tunis, Tunisia; Research Laboratory, LR18SP06, Tunis, Tunisia

Journal volume & issue: Vol. 23
p. 200470

Abstract

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Perivascular epithelioid cell (PEC) tumors (PEComas) are a family of related mesenchymal tumors composed of PECs that co-express melanocytic and smooth muscle markers. Their diagnosis is challenging in the female genital organs owing to its morphologic and immunohistochemical overlap with smooth muscle tumors and other clear cell tumors. We report the clinicopathologic and immunohistochemical characteristics. We also discuss differential diagnoses of an unusual tumor of the uterus composed of nodules of epithelioid cells strongly positive for HMB45, arising in a surrounding leiomyoma. We viewed these neoplasms as PEComa. The follow up has shown that the patient was alive without disease 1 year after the surgery.

Published in Human Pathology: Case Reports

ISSN: 2214-3300 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Pathology
Website: http://www.journals.elsevier.com/human-pathology-case-reports/

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