Nature Communications (Apr 2020)
Integrative functional genomics decodes herpes simplex virus 1
- Adam W. Whisnant,
- Christopher S. Jürges,
- Thomas Hennig,
- Emanuel Wyler,
- Bhupesh Prusty,
- Andrzej J. Rutkowski,
- Anne L’hernault,
- Lara Djakovic,
- Margarete Göbel,
- Kristina Döring,
- Jennifer Menegatti,
- Robin Antrobus,
- Nicholas J. Matheson,
- Florian W. H. Künzig,
- Guido Mastrobuoni,
- Chris Bielow,
- Stefan Kempa,
- Chunguang Liang,
- Thomas Dandekar,
- Ralf Zimmer,
- Markus Landthaler,
- Friedrich Grässer,
- Paul J. Lehner,
- Caroline C. Friedel,
- Florian Erhard,
- Lars Dölken
Affiliations
- Adam W. Whisnant
- Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Versbacher Straße 7
- Christopher S. Jürges
- Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Versbacher Straße 7
- Thomas Hennig
- Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Versbacher Straße 7
- Emanuel Wyler
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine
- Bhupesh Prusty
- Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Versbacher Straße 7
- Andrzej J. Rutkowski
- Department of Medicine, University of Cambridge, Box 157, Addenbrookes Hospital
- Anne L’hernault
- Department of Medicine, University of Cambridge, Box 157, Addenbrookes Hospital
- Lara Djakovic
- Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Versbacher Straße 7
- Margarete Göbel
- Core Unit Systems Medicine, Julius-Maximilians-University Würzburg
- Kristina Döring
- Core Unit Systems Medicine, Julius-Maximilians-University Würzburg
- Jennifer Menegatti
- Institute of Virology, Building 47, Saarland University Medical School
- Robin Antrobus
- Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, Cambridge Biomedical Campus, University of Cambridge
- Nicholas J. Matheson
- Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, Cambridge Biomedical Campus, University of Cambridge
- Florian W. H. Künzig
- Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Versbacher Straße 7
- Guido Mastrobuoni
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine
- Chris Bielow
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine
- Stefan Kempa
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine
- Chunguang Liang
- Department of Bioinformatics, Biocenter, Am Hubland, Julius-Maximilians-University Würzburg
- Thomas Dandekar
- Department of Bioinformatics, Biocenter, Am Hubland, Julius-Maximilians-University Würzburg
- Ralf Zimmer
- Institute of Informatics, Ludwig-Maximilians-Universität München
- Markus Landthaler
- Berlin Institute for Medical Systems Biology, Max-Delbrück-Center for Molecular Medicine
- Friedrich Grässer
- Institute of Virology, Building 47, Saarland University Medical School
- Paul J. Lehner
- Cambridge Institute of Therapeutic Immunology & Infectious Disease (CITIID), Department of Medicine, Cambridge Biomedical Campus, University of Cambridge
- Caroline C. Friedel
- Institute of Informatics, Ludwig-Maximilians-Universität München
- Florian Erhard
- Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Versbacher Straße 7
- Lars Dölken
- Institute for Virology and Immunobiology, Julius-Maximilians-University Würzburg, Versbacher Straße 7
- DOI
- https://doi.org/10.1038/s41467-020-15992-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 14
Abstract
Here, using computational integration of multi-omics data, the authors provide a detailed transcriptome and translatome of herpes simplex virus 1 (HSV-1), including previously unidentified ORFs and N-terminal extensions. The study also provides a HSV-1 genome browser and should be a valuable resource for further research.
