Nature Communications (Nov 2018)

Kauniolide synthase is a P450 with unusual hydroxylation and cyclization-elimination activity

  • Qing Liu,
  • Arman Beyraghdar Kashkooli,
  • David Manzano,
  • Irini Pateraki,
  • Lea Richard,
  • Pim Kolkman,
  • Maria Fátima Lucas,
  • Victor Guallar,
  • Ric C.H. de Vos,
  • Maurice C. R. Franssen,
  • Alexander van der Krol,
  • Harro Bouwmeester

DOI
https://doi.org/10.1038/s41467-018-06565-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

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Guaianolides are pharmaceutically interesting molecules. Here, the authors isolate the enzyme kauniolide synthase from feverfew, show that it converts constunolide into a guaianolide via an unusual mechanism of action, and reconstruct the full kauniolide biosynthesis pathway in host organisms.